Certain aminoxyethyl derivatives of 2(1h)-pyridones



United States Patent 3 Claims JJHzCHzONHz wherein R is selected from the group consisting of hydrogen and methyl;

CHzCHzONHz wherein Z is selected from the group consisting of hydrogen, halogen, trifiuoromethyl, alkylthio, alkanoyl, alkyl, and alkoxy; and

2 I? l H H3cH20NH2 wherein 2 has the same meaning as above.

Examples of halogen in the above Formulas Ib and 16 are fluorine, chlorine, bromine, and iodine. Examples of alkyl in the alkylthio, alkanoyl, alkyl, and alkox substituents are methyl, ethyl, propyl, butyl, pentyl, and isomeric forms thereof.

The novel isopropylideneaminooxyethyl compounds, which are intermediates for the preparation of the aminooxyethyl compounds (I) delineated in the preceding formulas, are represented by the respective formulae 3,431,270 Patented Mar. 4, 1969 N on, (I:

HzCHzON=C and N C H:

C H1CHzON=C CH| (I10) wherein R and Z have the same meaning as above.

The novel compounds of Formula I exist in their nonprotonated (free base) or protonated forms depending on the pH of their environments. They form stable protonates (acid addition salts) on neutralization with acids, for example, hydrochloric, hydrobromic, sulfuric, phosphoric, nitric, thiocyanic, fiuosilicic, acetic, benzoic, salicylic, glycolic, succinic, niotinic, tartaric, maleic, malic, lactic, methanesulfonic, and cyclohexanesulfamic acids, and the like. These acid addition salts are useful in upgrading the free bases. The corresponding free bases are useful as acid acceptors in neutralizing undesirable acidity or in absorbing an acid as it is formed in a chemical reaction, for example, a dehydrohalogenation reaction in which hydrogen and chlorine, bromine or iodine, are removed from vicinal carbon atoms.

The thiocyanic acid addition salts of the compounds of Formula I, i.e., the 1-(2-aminooxyethyl)-2(1H)-pyridones, lO-(Z-aminooxyethyl)phenothiazines and 5 (2- aminooxyethyl) 10,1l-dihydro-SH-dibenz[b,f]azepines. when condensed with formaldehyde, from resinous materials useful as pickling inhibitors according to US. Patents 2,425,320 and 2,606,155. The fluosilicic acid addition salts of the compounds of Formula I are useful as mothproofing agents according to US. Patents 1,915,- 334 and 2,075,359.

The novel 1 (2 aminooxyethyl) s;2(lH) pyridones (la), l0-(2-aminooxyethyl)phenothiazines (Ib) and 5- (Z-a-minooxyethyl -10,1 l-dihydro-S H-dibenz[b,f] azepines (10) of the invention can be prepared (in the form of their acid addition salts) by the acid hydrolysis of the corresponding l-[2 (isopropylideneaminooxy)ethyl] 2- 1H) -pyridones (-Ila) 10- [2-(isopropylideneaminooxy ethy1]phenothiazines (Ilb) and S-[Z-(isopropylideneaminooxy)ethyl] 10,11 dihydro 5H dibenz[b,f] azepines (He). The hydrolysis advantageously is effected with hydrochloric acid, although other acids, particularly other mineral acids, e.g., hydrobromic or sulfuric acids can be used. The products (I) are recovered from the reaction mixture by conventional procedures; for example, by solvent evaporation, recrystallization, and the like. The resulting acid addition salts of Formula I can be converted to their free bases by treatment with an alkali metal hydroxide, e.g., aqueous sodium or potassium hydroxide, and the liberated free bases can be converted to other acid addition salts by neutralization with an acid, for example, any of the acids given above. Acid addition salts can also be formed by metathesis.

The novel 1 [2 isopropylideneaminooxy)ethyl] 2- (1H)-pyridones (Ila), 10-[2-(isopropylideneaminooxy)- ethyl]phenothiazines (Ilb) and S-[Z-(isopropylideneaminooxy) ethyl]-10,1 1-dihydro-5H-dibenz[b,f]azepines (I10) of the invention are prepared by the metathesis of an alkali metal salt of the respective formulae (IVs) Z I lit and f M (IVc) wherein R and Z have the same meaning as above, and M is an alkali metal (e.g., sodium, potassium and lithium), with 2-(isopropylideneaminooxy)ethyl p-toluenesulfonate of the formula /C=NO CHzCHzOSOr-QCH:

CH; (III) The metathetic reaction can advantageously be carried out at elevated temperatures, preferably between about 50 and about 100 C., in the presence of an inert solvent, e.g., methanol, ethanol, isopropyl alcohol, t-butyl alcohol, benzene, toluene, xylene, dimethylformamide, and the like. A heating period of about two to ten hours is sufficient to effect substantial completion of the reaction. The products (II) are recovered from the reaction mixture by conventional procedures; for example, by evaporation to dryness followed by extraction with inert solvents (e.g., ethanol, ether, methylene chloride, and mixtures thereof); separation (e.g., filtration); distillation in vacuo; chromatography, etc.

More particularly, the alkali metal salt of Formula Na in the form of a dry powder is mixed with with an inert solvent of the kind mentioned above; or an alkanol solution of an alkali metal alkoxide is prepared, e.g., by adding sodium to methanol, ethanol, or isopropyl alcohol, or potassium to t-butyl alcohol, and then adding a 2- (1H)-pyridone of the formula wherein R has the same meaning as above, to form the alkali metal salt (IVa) in situ; or a 2-(1I-I)-pyridone (Va) is reacted with an alkali metal hydride or alkali metal amide, e.g., sodium hydride, lithium hydride, sodium amide, potassium amide, and the like, in the presence of an inert solvent of the kind mentioned above, to form that alkali metal salt (Na) in situ. To the thus-prepared medium containing the alkali metal salt (IVa) is then added the sulfonate (III), and the metathetic reaction is carried out as described above.

Similar considerations apply to the preparation of media comprising an inert solvent of the kind mentioned above and an alkali metal salt of Formula IVb or IVc. When said salt is to be formed in situ, it is preferred to react an alkali metal hydride or alkali metal amide with 4 a phenothiazine or 10,1l-dihydro-5Hdibenz[b,f]azepine of the respective formulae i H (Vb) and wherein 2 has the same meanings as above. Advantageously, the reaction (replacement of N-attached hydogen with alkali metal) is carried out in the presence of dimethylformamide, preferably at a temperature between about 50 and about 75 C. in the case of Compound Vb, and preferably between about C. and the reflux temperature of the mixture in the case of Compound Vc. To the thus-prepared medium containing the alkali metal salt (IVb or We) is then added the sulfonate (III), and the metathetic reaction is carried out as described above.

The compound of Formula In is prepared by reacting Z-(isopropylideneaminooxy)ethanol with p-toluenesulfonyl chloride or p-toluenesulfonyl bromide. Advantageously, the reaction is carried out in the presence of an inert solvent, e.g., pyridine, picoline, benzene, toluene, and the like, and an acid acceptor, e.g., triethylamine, N- methylpiperidine, and the like, at temperatures between about -20 and about +20 C., particularly between about l0 and about +10 C. When employing a basic inert solvent such as pyridine or picoline (which are also good acid acceptors), no additional acid acceptor need be employed.

The novel compounds of Formula II, and those of Formula I in their free base form and in the form of their acid addition salts with pharmacologically acceptable acids, for example, hydrochloric, hydrobromic, sulfuric, phosphoric, nitric, acetic, benzoic, salicylic, glycolic, succinic, nicotinic, tartaric, maleic, malic, lactic, methanesulfonic, and cyclohexanesulfamic acids, and the like, exhibit pharmacological activity. The compounds of Formula I possess central nervous system depressing, antiinflammatory and anorexigenic properties. They can be used, respectively, for producing sedation, in the treatment of inflammatory conditions of the skin, eyes, and respiratory tract, and in alleviating hunger and reducing overweight, in mammals and animals, e.g., mice, rats and birds. The compounds of Formula II are active inhibitors of the enzyme S-hydroxytryptophan decarboxylase; they are useful as central nervous system depressants and can be used for producing sedation in mammals and animals, e.g., mice, rats and birds.

The novel compounds of Formula I can be used in the preparation of the corresponding anorexigenic guanidines, by reacting the former with 2-methyl-2-thiopseudourea sulfate, or with cyanamide. For example, treating 1-(2- aminooxyethyl) 2(1H) pyridone, l0 (2 aminooxyethyl)phenothiazine and 5 (2 aminooxyethyl) 10,11- dihydro 5H dibenz[b,f]azepine with the aforesaid reagents by the methods disclosed in J. Chem. Soc. 963 (1947) for the preparation of l-alkoxyguanidines, yields, respectively, 1 (2 guanidinooxyethyl) 2(1I-I) pyridone, 10 (2 guanidinooxyethyl)phenothiazine, and 5 (2 guanidinooxyethyl) 10,11 dihydro 5H dibenz [b,f]azepine. The fl-uosilicic acid addition salts of the thus-produced compounds are useful as mothproofing agents according to U.S. Patent 2,205,789. l-(2-guanidinooxyethyl) 2(lI-I) pyridone, 10 (2 guanidinooxyethyl)phenothiazine, and S (2 guanidinooxyethyl) 10,11 dihydro 5H dibenz[b,f]azepine are also useful Preparation 1 .2 1H -pyridone sodium salt To a solution of 23 g. (1 g. atom) of sodium metal in ethanol is added 95 g. (1 mole) of 2(lH)-pyridone and the solution is heated at refluxing temperature for a period of about 30 minutes. The solution is evaporated to dryness under reduced pressure to yield 2(1H)-pyridone sodium salt as a dry powder.

Following the procedure of Preparation 1 but substituting lithium for sodium yields 2(lH)-pyridone lithium salt.

Following the procedure of Preparation 1 but substituting methanol, isopropyl alcohol or t-butyl alcohol for ethanol, also yields 2(1H)-pyridone sodium salt.

Following the procedure of Preparation 1 but substituting for 2( lH)-pyridone the following:

3-methyl-2(1H)-pyridone (prepared as in J. Amer. Chem.

Soc., 76, 1286),

4-methyl-2( 1H) -pyridone Soc., 71,1186),

5-methyl-2( lI-l)-pyridone Soc., 68, 2574), and

6-methyl-2(1H)-pyridone (prepared as in Chem. Ber., 84,

296), yields, respectively,

3-methyl-2( lH)-pyridone sodium salt, 4-methyl-2 lH)-pyridone sodium salt, 5-methyl-2( 1H -pyridone sodium salt, and 6-methyl-2(1H)-pyridone sodium salt.

Example l.2-(isopropylideneaminooxy)ethyl p-toluenesulfonate (prepared as in J. Amer. Chem.

(prepared as in J. Amer. Chem.

, C., 95 g. (1.2 moles) of pyridine was added dropwise over a 30-minute period. After completing the addition the mixture was stirred for another 1.5 hours at 0 C. The reaction mixture was poured onto 1 liter of ice water containing crushed ice. After remaining in a refrigerator for 1 hour, the mixture (the organic phase of which had crystallized) was extracted with three 500-ml. portions of ether. The combined extracts were washed successively with 500 ml. of cold, dilute sulfuric acid containing ice chips, 500 ml. of ice water, 500 ml. of cold, dilute potassium hydroxide containing ice chips, and 500 ml. of ice water. The ethereal solution was dried over magnesium sulfate, filtered, and evaporated, to give 164 g. (94.4% yield) of a colorless liquid that crystallized and had a melting point of 34 to 39 C. Four recrystallizations of this material from a mixture of ether and Skellysolve B (hexane hydrocarbons) gave an analytical sample of 2-(isopropylideneaminooxy)ethyl p-toluenesulfonate as white needles melting at 39.5 to 41.0 C.

Analysis-Calm. for C H NO S: C, 53.11; H, 6.32; N, 5.16. Found: C, 53.18; H, 6.32; N, 5.10.

Example 2 (A) .1-[2-(isopropylideneaminooxy) ethyl]-2-(1H) -pyridone and hydrochloride (Ha) A mixture of 11.7 g. (0.10 mole) of 2(1H)-pyridone sodium salt from Preparation 1 and 27.1 g. (0.10 mole) of 2 isopropylideneaminooxy)ethyl p toluenesulfonate from Example 1 in 150 ml. of absolute ethanol was refluxed for 6 hours. The mixture was cooled, then filtered to remove the precipitated sodium p-toluenesulfonate, and the filtrate was concentrated under reduced pressure. The residue was treated with a 1:1 (by volume) mixture of ethanol and ether, and the mixture was filtered and concentrated. The resulting dark brown residue was distilled in vacuo to give 8.2 g. (42.2% yield) of colorless liquid product, 1-[2-(isopropylideneaminooxy) ethyl]-2(1H)-pyridone, with a boiling point of 125 to 133 C. at 0.25 mm. pressure; u 1.5316. The hydrochloride was prepared byadding an ethereal hydrogen chloride solution to a solution of the free base 'in ether; after three recrystallizations from a mixture of ethanol and ether, an analytical sample of l-[2-(isopropylideneaminooxy)ethyl] 2 (1H) pyridone hydrochloride was obtained in the form of white beads with a melting point of to 116 C.;

v:i,' 1715 cm? (pyridone carbonyl); A212 277 my (e=6,600) and 303 m (e=5,300)

Analysis.-Calcd. for C I-I ClN O C, 52.06; H, 6.55; H, 12.15. Found: C, 51.96; H, 6.85; N, 12.13.

On neutralization with sodium hydroxide or potassium hydroxide, the free base form, 1-[2-(isopropylideneaminooxy)ethyl]-2(1H)-pyridone, is obtained.

Following the procedure of part A of Example 2 but substituting hydrogen bromide or sulfuric acid for hydrogen chloride gives the corresponding acid addition salt, i.e., the hydrobrornide or sulfate, of 1-[2-(isopropylideneaminooxy ethyl] 2( 1H -pyridone.

Following the procedure of part A of Example 2. but substituting for 2(1H)-pyridone sodium salt:

3-methyl-2(1H)-pyridone sodium salt, 4-methyl-2(1H)-pyridone sodium salt, 5-methyl-2(1H)-pyridone sodium salt, and 6-methyl-2(1H)-pyridone sodium salt,

and if desired, employing the modification of the im' mediately preceding paragraph, yields, respectively,

(B) l0-[2-(isopropylideneaminooxy)ethyl] phenothiazine (Ilb) To a stirred suspension of 2.4 g. (0.1 mole) of sodium hydride in 200 ml. of dry, purified dimethylformamide, protected by an atmosphere of nitrogen, was added in two portions, 19.9 g. (0.1 mole) of phenothiazine. After heating to 50 to 60 C. for 2 hours with stirring, the reaction mitxure was cooled in ice and a solution of 27.1 g. (0.1 mole) of 2-(isopropylideneaminooxy)ethyl p-toluenesulfonate (from Example 1) in 50 ml. of dimethylformamide was added dropwise below 10 C. The solution was heated at 60 to 70 C. for 2 hours and stirred for about 15 hours at about 25 C. The major portion of the solvent was removed under reduced pressure and the residue was poured into 500 ml. of cold water. The insoluble material was extracted with three 200-ml. portions of methylene chloride; the combined extracts were dried, filtered, and evaporated. The resulting brown oil was chromatographed on neutral alumina; elution with a mixture of Skellysolve B (hexanes) and acetone (19:1 by volume) gave 26.3 g. (88.3% yield) of pale yellow crystalline product melting at 66 to 67 C. Recrystallization from Skellysolve B yielded fine white needles of l0-[2-(isopropylideneaminooxy)ethyl]phenothiazine with a melting point of 68 to 69 C., identical with the compound prepared in Example 4, below.

Following the procedure of part B of Example 2, but substituting for phenothiazine: 2-chlorophenothiazine, l-chlorophenothiazine, 3-fluorophenothiazine, 4-bromophenothiazine, Z-trifluoromethylphenothiazine,

Z-methylthiophenothiazine, 2-ethylthiophenothiazine, l-butylthiophenothiazine, 2-acetylphenothiazine, 2-valerylphenothiazine, 4-propionylphenothiazine, 2-methylphenothiazine, 2-t-butylphenothiazine, 2-isopropylphenothiazine, 2-pentylphenothiazine, 4-ethylphenothiazine, 2-methoxyphenothiazine, l-ethoxyphenothiazine, 3-propoxyphenothiazine, and 4isopentyloxyphenothiazine,

yields, respectively,

2-chloro-10- [2 (isopropylideneaminooxy)ethyl]phenothiazine,

l-chloro 10 [2 isopropylideneaminooxy)ethyl]phenothiazine,

3-fluoro 10 [2 (isopropylideneaminooxy)ethyl]phenothiazine,

4-bromo-10 [2 (isopropylideneaminooxy)ethyl]phenothiazine,

Z-trifluoromethyl-lO-[Z (isopropylideneaminooxy)ethyl] phenothiazine,

2-methylthio 10 [2 (isopropylideneaminooxy)ethyl] phenothiazine,

2 ethylthio 10 [2 (isopropylideneaminooxy)ethyl] phenothiazine,

1 -butylthio 10 [2 (isopropylideneaminooxy)ethyl] phenothiazine,

2-acety1 10 [2 (isopropylideneaminooxy)ethyl]phenothiazine,

2-valeryl-10 [2 (isopropylideneaminooxy)ethyl]phenothiazine,

4 propionyl 10 [2 (isopropylideneaminooxy)ethyl] phenothiazine,

2-methyl-10- [2 (isopropylideneaminooxy)ethyl]pheno- .thiazine,

2t-butyl-10 [2 (isopropylideneaminooxy)ethyl]phenothiazine,

2 isopropyl 10 [2 (isopropylideneaminooxy)ethyl] phenothiazine,

2-pentyl 10 [2-(isopropylideneaminooxy)etlhyllphenothiazine,

4-ethyl 10 [2 (isopropylideneaminooxy)ethyHphenothiazine,

2-methoxy 10-[2-(isopropylideneaminooxy)ethyl]phenothiazine,

l-ethoxy 10 [2-(isopropylideneaminooxy)ethyl]phenothiazine 3-propoxy-10-[2 (isopropplidenearninooxy)ethyl1phenothiazine, and

4-isopentyloxy 10 [2 (isopropylideneaminooxy)ethyl] phenothiazine.

(C) -[2-(isopropylideneaminooxy)ethyl]-10,11- dihydro-SH-dibenz [b,f] aezpine (11c) To a stirred suspension of 2.4 g. (0.1 mole) of sodium hydride in 200 m1. of dry, purified dimethylformamide, protected by an atmosphere of nitrogen, was added 19.5 g. (0.1 mole) of 10,11dihydro-5H-dibenz[b,f]azepine, The mixture was refluxed with stirring for 1 hour and then cooled in ice while a solution of 27.1 g. (0.1 mole) of 2- (isopropylideneaminooxy-ethyl p-toluenesulfonate in 50 ml. of dimethylformamide was added dropwise below C. The solution was stirred and heated at 60 to 70 C. for 2 hours and then allowed to stand about 15 hours at about C. The major portion of the solvent was removed under reduced pressure and the residue was poured into 500 ml. of cold water. The insoluble material was extracted with three 200-ml. portions of methylene chloride; the combined extracts were dried, filtered, and evapo- 8 rated. The resulting dark oil was chromatographed on neutral alumina and eluted with Skellysolve B to give 17.85 g. (60.7% yield) of 5-[2-(isopropylideneaminooxy)ethyl]- 10,11-dihydro-5H-dibenz[b,f]azepine as a colorless oil.

Following the procedure of part C of Example 2, but substituting for 10,11-dihydro-5H-dibenz[b,f]azepine:

3-chloro-1 0, l l-dihydro-SH-dibenz [b,f 1 azepine, 1-bromo-l0,l l-dihydro-SH-dibenz [b,f] azepine, 4-fluoro 10,1 1-dihydro-5H-di-benz[b,f]azepine, 3-trifluoromethyl-10, 1 l-dihydro-SH-dibenz [b,f] azepine, 3-methylthio- 10,1 1-dihydro-5H-dibenz [b,f] azepine, 3-acetyl-10,11-dihydro-5H-dibenz[b,f]azepine, 2-butyryl-10,1 1-dihydro 5.H-dibenz[-b,f] azepine, 3-methyl- 10,1 l-dihydro-SH-dibenz [b,f] azepine, 2-ethyl-10, l l-dihydro-SH-dibenz [b,flazepine, l-isobutyl-10,l1-dihydro-5H-dibenz[b,f]azepine, 3-methoxy- 10, l l-dihydro-SH-dibenz [b,f] azepine, and 1-pentyloxy-10,1l-dihydro-SH-dibenz[b,flazepine,

yields, respectively,

Example 3 (A) .--1-(2-aminooxyethyl) -2( 1H) -pyridone hydrochloride (Ia) A solution of 13.4 g. (0.069 mole) of 1-[2-(isopropylideneaminooxy)ethyl]-2(lH)-pyridone from part A of Example 2 and ml. of 6 N hydrochloric acid was steam distilled for 0.45 hour. The solvent was removed under reduced pressure; 50 ml. of ethanol was added and evaporated. The resulting crystalline residue was recrystallized from a mixture of ethanol and ether and dried, to give 12.7 g. (97% yield) of white solid melting at 186 to 190 C. (with decomposition). Four recrystallizations of this material from ethanolether gave an analytical sample of fluffy white crystals of l-(2-aminooxyethyl)-2(lH)-pyridone hydrochloride with a melting point of 197 to 198 C. (with decomposition);

35" 1657 cm. (pyridone carbonyl); A512? substituting for l-[2-(isopropylideneaminooxy)ethyl]- 2(1H) pyridone the following compounds:

3-methyl-1- [2- (isopropylideneaminooxy ethyl -2( 1H) pyridone,

4-methyll- [2- isopropylideneaminooxy ethyl] -2( 1H) pyridone,

S-methyl-1-[2-(isopropylideneaminooxy)ethyl]-2(1H)- pyridone,

and

G-methyll- [2- (isopropylideneaminooxy ethyl] -2( 1H pyridone,

yields, respectively,

S-methyll (Z-aminooxyethyl -2( 1H -pyridone hydro chloride,

4-methyl-1-(2-amin0oxyethyl)-2(1H)-pyridone hydrochloride,

S-methyl- 1 2-aminooxyethyl -2 1H -py-ridone hydrochloride,

and

6-methyl-1-(Z-aminooxyethyl )-2-( 1H )-pyridone hydrochloride.

(B) l-(2-aminooxyethyl) phenothiazine hydrochloride (Ib) A mixture of 6.0 g. (0.20 mole) of l0-[2-(isopropylideneaminooxy)ethyl]phenothiazine from part B of Example 2, 75 ml. of 8 N hydrochloric acid, and 50 ml. of ethanol was refluxed (for about 3 hours) until solution was effected. The solution was steam distilled for about 1 hour. The liquid remaining in the still was evaporated to dryness. The resulting purple, gummy solid was taken up in ethanol, filtered through charcoal, and the filtrate was treated with ether and cooled. The resulting white solid material was filtered and dried to give 3.75 g. (63.5% yield) of product with a melting point of 158 C. (decomposition). Three recrystallizations from a mixture of ethanol and ether gave an analytical sample of shiny white plates of -(2-aminooxyethyl)phenothiazine hydrochloride with a melting point of 161 to 163 C. (decomposition).

Analysis.--Calcd. for C H CIN OS: C, 57.03; H, 5.13; N, 9.50. Found: C, 57.06; H, 4.96; N, 9.41.

On neutralization with sodium hydroxide or potassium hydroxide, the free base form, l0-(2-aminooxyethyl) phenothiazine, is obtained.

Following the procedure of part B of Example 3, but substituting for hydrochloric acid another acid, e.g., hydrobromic or sulfuric acid, gives the corresponding acid addition salt, i.e., the hydrobromide or sulfate, of 10- (Z-aminooxyethyl)-phenothiazine.

Following the procedure of part B of Example 3, but substituting for 10-[2-(isopropylideneaminooxy)ethyl] phenothiazine the following compounds:

2-chlorol 0- 2- (isopropylideneaminooxy ethyl] phenothiazine,

l-chloro- 10- 2-(isopropylideneaminooxy ethyl] phenothiazine,

3-fiuoro- 1 0- [Z-(isopropylideneaminooxy ethyl] phenothiazine,

4-bromo- 1 0- [2- (isopropylideneaminooxy )ethyl] phenothiazine,

Z-trifluoromethyl-IO- [2- (isopropylideneaminooxy) ethyl] phenothiazine,

2-methylthiol 0- [2-(isopropylideneaminooxy)ethyl] phenothiazine,

2-ethylthio-1 0- [2- (isopropylideneaminooxy) ethyl] phenothiazine,

l-butylthiol 0- [Z-(isopropylideneaminooxy) ethyl] phenothiazine,

2-acetyl-1 0- [2- (isopropylideneaminooxy) ethyl] phenothiazine,

2-valeryl-10- [2-(isopropylideneaminooxy) ethyl] phenothiazine,

4-propionyll 0- [2-(isopropylideneaminooxy ethyl] phenothiazine,

2-methyl- 10- [2-(isopropylideneaminooxy) ethyl] phenothiazine,

2-t-butyl-10- [2- (isopropylideneaminooxy ethyl phenothiazine,

2-isopropyl- 1 0 2- (isopropylideneaminooxy)ethyl] phenothiazine,

2-pentyl-10- [Z-(isopropylideneaminooxy) ethyl] phenothiazine,

4-ethyl-10- (isopropylideneaminooxy ethyl] phenothiazine,

Z-methoxy- 10- [2- (isopropylideneaminooxy ethyl] phenothiazine,

l-ethoxy-l 0- [2-( isopropylideneaminooxy ethyl] pheno' thiazine,

3-propoxy-1 0- [2- (isopropylideneaminooxy ethyl] phenothiazine, and

4isopentyloxy- 10- [2- (isopropylideneaminooxy) ethyl] phenothiazine,

yields, respectively,

2-chloro-10-(Z-aminooxyethyl )phenothiazine hyrochloride,

l-chlorol 0- (Z-aminooxyethyl phenothiazine hydrochloride,

3-fluorol 0-( Z-aminooxyethyl phenothiazine hydrochloride,

4-bromo-10-(2-aminooxyethyl) phenothiazine hydrochloride,

Z-trifiuoromethyll0- (Z-aminooxyethyl phenothiazine hydrochloride,

Z-methylthio-l0-(2-aminooxyethyl)phenothiazine hydrochloride,

2-etl1ylthio-10-(Z-aminooxyethyl)phenothiazine hydrochloride,

l-butylthio-10-(2-aminooxyethyl) phenothiazine hydrochloride,

Z-acetyl-10-(Z-aminooxyethyl)phenothiazine hydrochloride,

2-valeryl-lO-(Z-aminooxyethyl)phenothiazine hydrochloride,

4-propionyl-10- (2-aminooxyethyl phenothiazine hydrochloride,

2-methy1-l0-(Z-aminooxyethyl)phenothiazine hydrochloride,

2t-butyl-l0-(2-aminooxyethyl) phenothiazine hydrochloride,

2-isopropyl-10-(Z-aminooxyethyl) phenothiazine hydrochloride,

Z-pentyl-10-(2-aminooxyethyl)phenothiazine hydrochloride,

4-ethyl-10-(2-aminooxyethyl)phenothiazine hydrochloride,

Z-methoxy-lO-(Z-aminooxyethyl)phenothiazine hydrochloride,

l-ethoxy-IO-(2-aminooxyethyl)phenothiazine hydrochloride,

3-propoxy-10-(2-aminooxyethyl)phenothiazine hydrochloride, and

4-isopentyloxy-10-(2-aminooxyethyl) phenothiazine hydrochloride.

(C) 5-(2-an'tinooxyethyl)-10,l1-dihydro-5H-dibenz[b,f] azepine hydrochloride (Ic) A mixture of 17.7 g. (0.06 mole) of the oily 5-[2-(isopropylideneaminooxy)ethyl] 10,11 dihydro-SH-dibenz- [b,f]azcpine from part C of Example 2, ml. of 8 N hydrochloric acid, and 75 ml. of ethanol was refluxed for 1 hour and then steam distilled for 1 hour. The solution was concentrated under reduced pressure and the resulting dark residue was dissolved in ethanol. The ethanolic solution was filtered through a pad of charcoal and the almost colorless filtrate was treated with ether and cooled. The crystalline product that formed was 11 filtered and dried to give 11.4 g. (65.5% yield) of offwhite solid having a melting point of 184.5 to 187 C. (with decomposition). Three recrystallizations of this material from a mixture of ethanol and ether yielded, as shiny white platelets, 5-(2-aminooxyethyl)-10,1l-dihyd-ro- 5H-dibenz[b,f]azepine hydrochloride melting at 188 to 189 C. (with decomposition).

Analysis.Calcd. for C H CIN O: C, 66.08; H, 6.59; N, 9.64. Found: C, 65.93; H, 6.60; N, 9.48.

On neutralization with sodium hydroxide or potassium hydroxide the free base form, 5-(2-aminooxyethyl)- 10,1l-dihydro-SH-dibenz[b,fJazepine, is obtained.

Following the procedure of part C of Example 3, but substituting for hydrochloric acid another acid, e.g., hydrobromic or sulfuric acid, gives the corresponding acid addition salt, i.e., the hydrobromide or sulfate, of 5-(2- aminooxyethyl)-10,11-dihydro-5H-dibenz[b,f]azepine.

Following the procedure of part C of Example 3, but substituting for 5-[2 (isopropylideneaminooxy)ethyl]- 10,1l-dihydro-SH-dibenz[b,fJazepine the following compounds:

3-chloro-5-[2-(isopropylideneaminooxy)ethyl]-10,1 1-

dihydr-5H-dibenz[b,f] azepine,

l-bromo-S- [2- (isopropylideneaminooxy ethyl 10, l 1- dihydro-SH-dibenz [b,f] azepine,

4-fluoro-5-[2-(isopropylideneaminooxy) ethyl] -10, 1 1- dihydro-H-dibenz [b,f] azepine,

3-trifluoromethyl-5- [2-( isopropylideneaminooxy )ethyl] 10,1l-dihydro-5H-dibenz[b,f]azepine,

3-methylthio-5-[2-(isopropylideneaminooxy) ethyl] -10,

ll-dihydro-SH-dibenz [b,f] azepine,

3-acetyl-5- [2- isopropylidene aminooxy ethyl] -1 0,1 1-

dihydro-SH-dibenz b,f] azepine,

2-butyryl-5- [2-(isopropylideneaminooxy) ethyl 10,1 1-

dihydro-SH-dibenz [b,f] azepine,

3-methyl-5-[2-(isopropylideneaminooxy)ethyl]-10,1l-

dihydro-SH-dibenz b,f] azepine,

Z-ethyl-S- [2- (isopropylideneaminooxy) ethyl] 1 0,1 1-

dihydro-SH-dibenz [b,f] azepine,

l-isobutyl-S- [2-( isopropylideneaminooxy ethyl] -l0,1 1-

dihydro-SH-dibenz [b,f] azepine,

3-methoxy-5- [2-(isopropylideneaminooxy) ethyl] 10, 1 1- dihydro-SH-dibenz b,f] azepine, and

l-pentyloxy-S- 2- isopropylideneaminooxy)ethyl l 0,1 1-

dihydro-SH-dibenz [b,f] azepine,

yields, respectively,

3-chloro-5-(2-aminooxyethyl -10, 1 l-dihydro-SH-dibenz [b,f] azepine hydrochloride, 1-bromo-5-(2-aminooxyethyl -10,1 l-dihydro-SH-dibenz[b,f] azepine hydrochloride, 4-fiuoro-5-(2-aminooxyethyl)-10,1l-dihydro-SI-ll-dibenz[b,f] azepine hydrochloride, 3-trifiuoromethyl-5-(2-aminooxyethyl)-10,1 l-dihydro- 5H-dibenz[b,f] azepine hydrochloride, 3-methylthio-5-(2-aminooxyethyl)-10,1l-dihydro-SH- dibenz[b,f] azepine hydrochloride, 3-acetyl-5-(Z-aminOOxyethyD-IO,1l-dihydro-SH-dibenz [b,f] azepine hydrochloride, 2-butyryl-5-(2-aminooxyethyl)-10,1 l-dihydro-SH-dibenz[b,f] azepine hydrochloride, 3-methy1-5-( 2-aminooxyethyl)-10, 1 l-dihydro-SH-di- 'benz [b,f] azepine hydrochloride, Z-ethyl-5-(2-aminooxyethyl)-10,l l-dihydro-SH-dibenz[b,f] azepine hydrochloride, l-isobutyl-5-(-aminooxyethyl -20,1 l-dihydro-SH-dibenz[b,f] azepine hydrochloride, 3-methoxy-5-(2-aminooxyethyl)-10,11-dihydro-5I-I-dibenz[b,f] azepine hydrochloride, and l-pentyloxy-S-(2-aminooxyethyl)-10,1 l-dihydro-SH-dibenz[b,f] azepine hydrochloride.

12 Example 4.--[2-(isopropylideneaminooxy)ethyl] phenothinzine (IIb) (a) A solution of 60.8 g. (0.25 mole) of lfl-phenothiszineethanol in 250 ml. of dry, purified dioxane was treated with 5.75 g. (0.25 g.-atom) of sodium metal and the mixture was refluxed with stirring until the sodium had dissolved, which required about 4 hours. After the solution had cooled to room temperature, 250 ml. of a cold (50 to -40 C.) ether solution containing approximately 0.25 mole of chloramine (ClNH was added in several portions. After the addition was completed, the mixture was cooled in ice to prevent the ether from refluxing. After 10 minutes the ice bath was removed and the mixture was stirred for about hours at about 25 C. The resulting deep purple material was filtered and the major portion of the solvents were removed under reduced pressure. The residue was treated with 500 ml. of anhydrous ether and the mixture was refiltered. The filtrate was made slightly acidic with ethanolic hydrogen chloride. After several minutes, the supernatant liquid was decanted from the black oil that had separated. The black oil was treated with 600 ml. of aqueous sodium hydroxide solution and the mixture was extracted with three 300ml. portions of methylene chloride. The combined organic extracts were washed with 300 ml. of water, dried with anhydrous magnesium sulfate, filtered, and evaporated to obtain crude 10-(2-aminooxyethyl) phenothiazine as a dark gum.

(b) The product of (a) was chromatographed on a column containing about 350 g. of Florisil (synthetic magnesium silicate). No material was obtained by elution with eight 400-ml. portions of Skellysolve B. The column was then eluted with a mixture of Skellysolve B and acetone (19:1 by volume). This eluate was evaporated to dryness to obtain a light reddish-brown oil which crystallized. On recrystallization of this material from Skellysolve B, there was obtained 10-[2-(isopropylideneaminooxy)ethyl]phenothiazine as a light orange solid having a melting point of 64.5 to 66 C. Six more crystallizations from Skellysolve B yielded the compound as colorless needles having a melting point of 67 to 68 C.

Analysis.-Calcd. for C I-1 N 08: C, 68.42; H, 6.08; N, 9.39; S, 10.75. Found: C, 68.13; H, 5.80; N, 9.24; S, 10.79.

I claim:

1. A compound selected from the group consisting of (l) a compound of the formula:

JHzCHzONHI References Cited FOREIGN PATENTS 3/ 1959 Great Britain.

HENRY R. JILES, Primary Examiner.

A. L. ROTMAN, Assistant Examiner.

U.S. Cl. X.R. 

1. A COMPOUND SELECTED FROM THE GROUP CONSISTING OF (1) A COMPOUND OF THE FORMULA: 